“They had four chances and scored three times, they deserved their victory,” said Portugal coach Fernando Santos. “Two years ago, before the Euros, we lost at home against Bulgaria. I don’t think we have lost confidence, I still believe in these players for the future.”
The Netherlands, who lost 1-0 to England in Amsterdam on Friday, opened the scoring in the 11th minute as Depay grabbed the first goal of the Koeman era by turning home from inside the box.
That strike came against the run of play as Portugal had dominated the early stages against an unusual 5-3-2 formation deployed by the Dutch.
Ronaldo was left incensed after his appeals for a penalty were waved away, despite replays appearing to show him kick the ground when attempting to shoot.
But the Netherlands doubled their lead just after the half-hour mark as Ryan Babel headed in Matthijs de Ligt’s driven cross from close range.
The goal continued the Besiktas winger’s return to form, having only been recalled to the Dutch squad last year after a six-year absence.